Can aripiprazole cause brain damage?

In the brain tissue, aripiprazole did not induce DNA damage in any of the treatments (Table 1), although it caused impairment of neurobehavioral performance.

Does aripiprazole help with anxiety?

Results: A number of studies have shown atypical antipsychotics to be effective in anxiety, and currently available data suggest that aripiprazole augmentation in patients with anxiety disorders is likely as effective as other atypical antipsychotic drugs.

Will aripiprazole keep me awake?

It’s possible to have sleepiness or insomnia while you’re taking Abilify. With insomnia, you’re unable to fall asleep or stay asleep. This condition may cause sleepiness during the hours that you’re awake. If you or your child has insomnia or sleepiness after taking Abilify, talk with your doctor.

How is aripiprazole metabolized?

Aripiprazole is mainly metabolized by human cytochrome P450 (CYP) isozymes CYP3A4 and CYP2D6 to dehydroaripiprazole and several other metabolites [19]. In turn, dehydroaripiprazole is metabolized only by CYP3A4 and CYP2D6 into several components, and the derived metabolites are excreted in urine or feces [20].

What are the side effects of aripiprazole?

Check with your doctor immediately if any of the following side effects occur while taking aripiprazole: large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs Get emergency help immediately if any of the following symptoms of overdose occur while taking aripiprazole:

Is aripiprazole adaptive?

The other relevant consequence of the ‘adaptive’ feature of aripiprazole is that the pharmacological action of the compound may strictly depend on, among other mechanisms, the endogenous dopamine levels and signaling status.

Does aripiprazole cause drug-drug interactions at the BBB?

These findings indicate that aripiprazole is unlikely to cause drug-drug interactions (DDIs) at the BBB when co-administered with substrate drugs of these drug transporters investigated. However, interactions at the intestinal absorption process may be of concern. Copyright © 2012 John Wiley & Sons, Ltd.