Can gentamicin be given once-daily?

A once-daily dosing regimen of gentamicin is at least as effective as and is less nephrotoxic than more frequent dosing.

How is gentamicin calculated for kids?

The daily dose recommended in children aged 1 year and above and adolescents with normal renal function, is 3 – 6 mg/kg/day as one single dose (preferred) or two divided doses. The daily dose in infants after the first month of life is 4.5 – 7.5 mg/kg/day as one single dose (preferred) or two divided doses.

How often can gentamicin be given?

When gentamicin is injected intravenously, it is usually infused (injected slowly) over a period of 30 minutes to 2 hours once every 6 or 8 hours. The length of your treatment depends on the type of infection you have. You may receive gentamicin injection in a hospital or you may administer the medication at home.

When should I take gentamicin levels?

Gentamicin levels should be taken 6-14 hours after the start of the infusion. For a daily dose of 5mg/kg/day the Urban-Craig nomogram can be used. Gentamicin levels should be taken 8-12 hours after the dose.

What are the contraindications of gentamicin?

Who should not take GENTAMICIN SULFATE?

  • low amount of calcium in the blood.
  • dehydration.
  • a type of movement disorder called parkinsonism.
  • myasthenia gravis, a skeletal muscle disorder.
  • ringing in the ears.
  • disorder of nerve that controls hearing and balance.
  • decreased kidney function.
  • sensation of spinning or whirling.

Can a child use gentamicin?

The dose of Gentamicin in children is 6 to 7.5 mg/kg/day (2 to 2.5 mg/kg administered every 8 hours). For infants and neonates, the dose is 7.5 mg/kg/day (2.5 mg/kg administered every 8 hours).

Can gentamicin be given IM in children?

As a result of these observations it is suggested that an intramuscular dose of 2-5 mg/kg given 8-hourly is suitable for most children in the absence of renal failure, but that adjustment of the dose according to serum gentamicin concentration is necessary.

How often should gentamicin levels be taken?

Pre-dose (trough) gentamicin levels should be checked after 24 hours and then twice weekly (target <1mg/L). Peak gentamicin levels, taken one hour after administration, can also be measured (target 3–5mg/L). Individualised dosing based on the patient’s pharmacokinetics can also be used.

When should gentamicin levels be taken after once daily administration?

Gentamicin levels should be taken 8-12 hours after the dose. It is essential that the time the gentamicin infusion was started and the time the sample was taken are documented accurately.

How often is IV gentamicin given?

1 to 2 mg/kg/dose IV every 8 hours for at least 6 weeks plus a beta-lactam. The FDA-approved dosage is 2 to 2.5 mg/kg/dose IV or IM every 8 hours. 2.5 mg/kg/dose IV or IM every 8 hours for at least 6 weeks plus a beta-lactam.

What is the peak and trough for gentamicin?

Reference Range

Trough Gentamicin levels Peak Gentamicin levels
Optimal: 0.5-2 µg/mL Optimal: 5-10 µg/mL
Toxic: >2 µg/mL Toxic: >12 µg/mL

Is once-daily dosing of gentamicin a safe method of treatment?

Conclusions: These data confirm that once-daily dosing of gentamicin is a safe method of treatment that provides equivalent pharmacokinetics compared with traditional dosing and enhances bactericidal effect based on higher peak levels, avoids toxicity, and allows cost savings. Adolescent Analysis of Variance

Who is eligible for gentamicin therapy?

Children between 6 months and 18 years who required gentamicin therapy based on independent clinical assessment were eligible if they had normal renal function, no aminoglycoside allergies, were not neutropenic, or did not have cystic fibrosis.

What is the usual dose of neonate for the intraventricular?

-The usual intraventricular dose was 1 to 2 mg/day. -The intraventricular drain should be clamped for approximately 15 to 60 minutes to allow the drug to equilibrate. -Neonate duration of therapy is 2 weeks beyond the first sterile CSF culture OR at least 3 weeks, whichever is longer. -The usual intraventricular dose was 1 to 2 mg/day.

Is there a similar strategy for antibiotic treatment in children?

A similar strategy in children requires the characterization of pharmacokinetic parameters and the development of a therapeutic monitoring protocol for this antibiotic regimen. Methods: A prospective, controlled, randomized (2:1) study was undertaken in 50 pediatric patients between June 1995 and September 1997.