How do you counteract benzene exposure?

For short-term exposure to high levels of benzene, the Centers for Disease Control and Prevention (CDC) recommends getting away from the source of benzene, removing any clothing that may have benzene on it, washing exposed areas with soap and water, and getting medical care as soon as possible.

How does benzene affect the cell cycle?

Benzene suppresses the cell cycle by p53-mediated overexpression of p21, a cyclin-dependent kinase inhibitor, resulting not simply in suppression of hemopoiesis but rather in a dynamic change of hemopoiesis during and after benzene exposure.

What is the route of exposure for benzene?

ROUTES OF EXPOSURE: Benzene can be absorbed into the body by inhalation, ingestion, or skin contact. Inhalation is an important route of exposure.

Can benzene enter the body through absorption?

A small amount will enter your body by passing through your skin and into your bloodstream during skin contact with benzene or benzene-containing products. Once in the bloodstream, benzene travels throughout your body and can be temporarily stored in the bone marrow and fat.

How long does benzene stay in your system?

within 48 hours
Benzene is quickly eliminated from your system, usually within 48 hours. It is converted to products, medically known as metabolites, in the liver and bone marrow. Some of the harmful consequences of benzene exposure are caused by these metabolites.

What concentration of benzene will cause initial signs of illness after 5 hours of exposure?

Generally, symptoms of CNS toxicity are apparent immediately after inhalation of high concentrations of benzene (3,000 ppm for 5 minutes), and 30 to 60 minutes after ingestion. Mild effects include headache, lightheadedness, dizziness, confusion, nausea, impaired gait, and blurred vision.

How does benzene affect DNA?

These results suggest that these benzene metabolites cause DNA damage through H2O2 generation in cells, preceding internucleosomal DNA fragmentation leading to apoptosis. The fates of the cells to apoptosis or mutation might be dependent on the intensity of DNA damage and the ability to repair DNA.

What is benzene poisoning?

Benzene poisoning occurs when someone swallows, breathes in, or touches benzene. It is a member of a class of compounds known as hydrocarbons. Human exposure to hydrocarbons is a common problem. This article is for information only. DO NOT use it to treat or manage an actual poison exposure.

How is benzene metabolized in the body?

Benzene is metabolized, primarily in the liver, to a variety of hydroxylated and ring-opened products that are transported to the bone marrow where subsequent secondary metabolism occurs.

What neutralizes benzene?

The level of benzene in blood can be efficiently reduced, an its noxious effect neutralized, by the concurrent administration of either of two groups of organic compounds: 1) methyl donors such as choline and betaine; and, 2) cysteine-HCL.

How is benzene excreted?

benzene metabolism, which results in the production of several reactive metabolites. metabolized and excreted predominantly as conjugated urinary metabolites. pathways appear to become saturated and a large portion of an absorbed dose of benzene is excreted as parent compound in exhaled air.

What are four known health effects of benzene exposure?

Acute (short-term) inhalation exposure of humans to benzene may cause drowsiness, dizziness, headaches, as well as eye, skin, and respiratory tract irritation, and, at high levels, unconsciousness.