How tall do people with Sotos get?
The weight is usually appropriate for the height and the bone age is advanced mean by 2 to 4 years over chronological age, during childhood. Adult height usually exceeds the average of normal men or women. Some individuals may reach excessive adult heights; males of 193 cm to 203 cm (6 ft. 4 in. to 6 ft.
What are the symptoms of Sotos syndrome?
Sotos syndrome is a disorder characterized by a distinctive facial appearance, overgrowth in childhood, and learning disabilities or delayed development of mental and movement abilities. Characteristic facial features include a long, narrow face; a high forehead; flushed (reddened) cheeks; and a small, pointed chin.
How is Sotos syndrome diagnosed?
A genetic test is part of the diagnosis process for Sotos syndrome. The test will check for a mutation in the NSD1 gene. It’s common for children with Sotos syndrome to receive a diagnosis of autism spectrum disorder. Your doctor can recommend behavioral and other types of therapy that may help.
Is Sotos syndrome autism?
The findings from the present study demonstrate a high prevalence of autistic symptomatology within the Sotos population and suggest that the majority of individuals with Sotos syndrome display clinically significant behavioural symptomatology associated with ASD.
Is Sotos syndrome genetic?
Inheritance. Sotos syndrome is inherited in an autosomal dominant manner. This means that having a mutation in only one of the 2 copies of the responsible gene (the NSD1 gene) is enough to cause signs and symptoms of the condition. 95% of people with Sotos syndrome do not inherit the condition from a parent.
What does a child with Sotos syndrome look like?
Children with Sotos syndrome have an extremely large skull (macrocrania) but the brain remains small. Although the skull is large, it appears high and narrow. The forehead is prominent, the eyes are wide-spaced and the nose and cheeks are rosy. The roof of the mouth is narrow and arched upward.
What is the cause of Sotos syndrome?
The primary cause of sotos syndrome is NSD1 gene mutation. What is NSD1 gene? It is the one responsible in providing instructions for making a protein that works as histone methyltransferase, an enzyme that modifies histone (structural protein) that is attached to the DNA.
How common is Sotos syndrome in adults?
As with the intellectual development, adults with Sotos syndrome are within the normal range for intellect. (1, 3, 4) How common is Sotos Syndrome? In every 14,000 newborn, one case of Sotos syndrome is reported. The clinical features of Sotos syndrome can be mistaken for other health conditions.
How is Sotos syndrome diagnosed and treated?
This suspected diagnosis can be confirmed through a genetic test to check changes in the NSD1 gene. Aside from the tall stature children with Sotos Syndrome are likely to encounter a number of other difficulties and symptoms.