What do lipopeptides do?

Lipopeptides exert their effect by binding and disrupting the cell membrane integrity of the target bacteria and initiating a series of events that eventually leads to cell death.

Where are lipopeptides found?

They are mainly obtained from bacteria (e.g., Bacillus and Pseudomonas genera) [15]. The lipopeptides are formed by a fatty acid (between C12 and C18) linked to a peptide chain (from 4 to 12 amino acids) [3,16]. These can be found with a linear hydrophilic head or a lactone ring if they are cyclic lipopeptides.

What is Iturins?

Iturins are a family of lipopeptides extracted from the culture media of various strains of Bacillus subtilis.

What is cyclic lipopeptide antibiotic?

Aminoglycoside antibiotics are used to treat bacterial infections like skin and skin structure infections, and infections in the bloodstream and heart. They disrupt cell membrane function, killing the bacteria cells causing the infection.

What drugs are Lipopeptides?


Drug Target Type
Daptomycin P-glycoprotein 1 transporter
Polymyxin B Bacterial outer membrane target
Polymyxin B Solute carrier family 15 member 2 transporter
Caspofungin Solute carrier family 22 member 1 transporter

What are bacterial lipopeptides?

Bacterial lipopeptides are amphiphilic molecules that consist of short linear chains or cyclic structures of amino acids, and including depsipeptides, i.e. peptides in which one or more of the amide bonds is replaced by an ester bond (or lactone in cyclic structures).

Is vancomycin a lipopeptide?

Vancomycin-Lipopeptide Conjugates with High Antimicrobial Activity on Vancomycin-Resistant Enterococci. Pharmaceuticals (Basel).

How do glycopeptides work?

Glycopeptide antibiotics work by inhibiting the cell wall synthesis of the bacteria. By attaching to its target (D-alanyl-D-alanine terminus) which is part of the cell wall, the invading bacteria are unable to divide and multiply.