What does the calcium-sensing receptor do?
The Ca2+-sensing receptor (CaSR) is a family C G protein-coupled receptor that is expressed on the cell surface as a dimer and signals via G proteins and β-arrestin. The CaSR regulates bone and mineral metabolism by influencing parathyroid hormone secretion, urinary Ca2+ excretion, skeletal development and lactation.
What type of receptor is the calcium-sensing receptor?
G-protein-coupled receptor
The extracellular calcium-sensing receptor (CaSR) is a G-protein-coupled receptor (GPCR) that is predominantly expressed in the parathyroids and kidneys, where it allows regulation of parathyroid hormone (PTH) secretion and renal tubular calcium re-absorption appropriate to the prevailing extracellular calcium …
What are calcimimetic drugs?
Calcimimetics are a group of drugs that are allosteric activators of the calcium-sensing receptor, thereby enhancing signaling and decreasing PTH release independent of vitamin D. 176. The only calcimimetic commercially available is cinacalcet HCl.
What signals does the calcium-sensing receptor respond to?
The Ca2+-sensing receptor (CaSR) is a dimeric family C G-protein-coupled receptor that is expressed in calcitropic tissues such as the parathyroid glands and kidneys, and signals via G-proteins and beta-arrestin.
What causes milk alkali syndrome?
Milk-alkali syndrome is almost always caused by taking too many calcium supplements, usually in the form of calcium carbonate. Calcium carbonate is a common calcium supplement. It is often taken to prevent or treat bone loss (osteoporosis). Calcium carbonate is also an ingredient found in antacids (such as Tums).
Where are the calcium-sensing receptors located?
the parathyroid gland
The calcium-sensing receptor (CaSR) is a Class C G-protein coupled receptor which senses extracellular levels of calcium ions. It is primarily expressed in the parathyroid gland, the renal tubules of the kidney and the brain.
What is the action of calcitonin?
Calcitonin’s main job is to lower calcium levels in your blood (not your bones). It does this in two main ways: Calcitonin inhibits (blocks) the activity of osteoclasts, which are cells that break down bone. When osteoclasts break down your bone, the calcium from your bone is released into your bloodstream.
What is a calcimimetic and why is it prescribed?
Calcimimetics (drugs that mimic the action of calcium on tissues) are a class of drugs used to treat hyperparathyroidism (a condition in which the parathyroid glands produce a high amount of parathyroid hormone [PTH]) in patients with chronic kidney disease (gradual loss of kidney function) who are being treated with …
Is sensipar a calcimimetic?
Sensipar (cinacalcet) is a calcimimetic agent that increases the sensitivity of the calcium-sensing receptor to activation by extracellular calcium.
Where are calcium receptors found?
parathyroid gland
Can drinking too much milk cause high calcium in blood?
Hypercalcemia may happen because cancer has spread to your bones, which causes calcium to be released. Or the cancer cells may make hormones that affect the systems controlling the amount of calcium in your blood. Hypercalcemia is not caused by drinking too much milk or by eating too many dairy products.
What is the calcium-sensing receptor?
The calcium-sensing receptor ( CaSR) is a Class C G-protein coupled receptor which senses extracellular levels of calcium ions. It is primarily expressed in the parathyroid gland, the renal tubules of the kidney and the brain. In the parathyroid gland, it controls calcium homeostasis by regulating the release of parathyroid hormone (PTH).
What is the calcium sensing receptor in the parathyroid?
The calcium-sensing receptor (CASR) is a plasma membrane G-protein coupled receptor (GPCR) that is expressed in the PTH-producing cells of the parathyroid gland and the cells lining the renal tubule (2,3). Calcium-Sensing Receptor and Vitamin D Receptor in Tissues Involved in Ca2+ Homeostasis 482
What family does the calcium receptor belong to?
The calcium receptor. The calcium receptor is a G protein-coupled receptor that shares structural homologies with other members of subfamily C receptors. This subfamily includes the metabotropic glutamate receptors (mGluRs), γ-aminobutyric acid type B receptors (GABA B Rs), and some pheromone and taste receptors.
What is the CaSR receptor and what does it do?
More recent research has shown the CaSR receptor to be involved in numerous other conditions including Alzheimer’s disease, asthma and some forms of cancer, and calcilytic drugs are being researched as potential treatments for these.