Why is magnesium sulfate used for eclampsia?

The mechanism of action of magnesium sulfate is thought to trigger cerebral vasodilation, thus reducing ischemia generated by cerebral vasospasm during an eclamptic event. The substance also acts competitively in blocking the entry of calcium into synaptic endings, thereby altering neuromuscular transmission.

Does magnesium sulfate treat eclampsia?

Magnesium sulfate (MgSO4) is the agent most commonly used for treatment of eclampsia and prophylaxis of eclampsia in patients with severe pre-eclampsia. It is usually given by either the intramuscular or intravenous routes.

Why do you give magnesium sulfate in pregnancy?

Magnesium sulfate is approved to prevent seizures in preeclampsia, a condition in which the pregnant woman develops high blood pressure and protein in the urine, and for control of seizures in eclampsia. Both preeclampsia and eclampsia are life-threatening complications that can occur during pregnancy.

How do you dilute MgSO4 for eclampsia?

Using a 20 mL syringe, draw 4 g of MgSO4 50% (8 mL) □ Add 12 mL sterile water or saline to the same syringe to make a 20% solution □ Give this 4g MgSO4 20% solution IV over 5 – 20 minutes. If convulsions recur after 15 minutes, give 2 g of MgSO4 20% by IV over 5 minutes.

What is the protocol for magnesium sulphate?

Magnesium sulphate is recommended as the first-line medication for prophylaxis and treatment of eclampsia. The loading dose is 4 g IV over 20 to 30 min, followed by a maintenance dose of 1 g/h by continuous infusion for 24 h or until 24 h after delivery, whichever is later.

What should you assess before giving magnesium sulfate?

Before beginning any infusion of magnesium sulfate, the primary RN will obtain baseline vital signs (temperature, pulse, respirations, blood pressure, and O2 saturation).

What are the signs of magnesium sulfate toxicity?

Monitor for signs and symptoms of magnesium sulfate toxicity (ie. hypotension, areflexia (loss of DTRs), respiratory depression, respiratory arrest, oliguria, shortness of breath, chest pains, slurred speech, hypothermia, confusion, circulatory collapse).

How fast do you give magnesium IV?

And finally, in the setting of OB emergencies such as severe pre-eclampsia or eclampsia, magnesium is thought to work in part through its effects on the NMDA receptor. In this setting, magnesium is given as a 4-6 gram load over 15-30 minutes, then a continuous infusion of 1-2 grams per hour.

What are the adverse effects of magnesium sulfate?

– Constipation – Hypomagnesemia – Prevention of seizures in eclampsia/preeclampsia – Acute nephritis (pediatric patients) – Cardiac arrhythmias secondary to hypomagnesemia – Soaking minor cuts or bruises

What are the complications of magnesium sulfate?

feeling like you might pass out;

  • sweating,anxiety,cold feeling;
  • flushing (warmth,redness,or tingly feeling);
  • weak or shallow breathing;
  • extreme drowsiness,feeling very weak; or
  • numbness or tingly feeling around your mouth,muscle tightness or contraction,overactive reflexes.
  • When to start magnesium in preeclampsia?

    •Consider giving intravenous magnesium sulfate if birth planned within 24 hours in woman with severe pre­eclampsia •Do not use diazepam, phenytoin or other anti­ convulsants as alternatives to magnesium sulfate in women with eclampsia Regimen for magnesium sulfate2,3 •Loading dose of 4 g given intravenously over 5 to 15 minutes,

    What is the therapeutic level of magnesium sulfate?

    Thereof, what is the therapeutic level of magnesium sulfate? Magnesium sulfate remains the standard in prevention and treatment of preeclamptic seizures or SE. It is given at a dose of 4 to 5 g IV, followed by an IV infusion of 1 g/hour, with the aim to reach a therapeutic level of 3.5 to 7 mEq/L, which corresponds to 4.2 to 8.4 mg/dL.