What is a key function of IL-2 during the adaptive immune response?

Interleukin-2 (IL-2) plays a crucial role in regulating immune responses and maintaining peripheral self-tolerance by having both immuno-stimulatory and immuno-regulatory functions.

What is an IL-2 inhibitor?

IL-2 is primarily involved in the regulation of T-lymphocytes proliferation but also activates natural killer (NK), B- and lymphokine-activated killer (LAK) cells. Inappropriate responses of T-lymphocytes are associated with a range of immune diseases, including allergies and autoimmune diseases.

What is IL-2 produced by?

activated CD4+ T cells
IL-2 is a typical four α helix cytokine and is produced primarily by activated CD4+ T cells, although expression by naive CD8+ T cells, dendritic cells, and thymic cells has also been reported (8, 9, 10, 11).

What type of cytokine is IL-2?

Interleukin-2 (IL-2) is a pleiotropic cytokine that drives T-cell growth, augments NK cytolytic activity, induces the differentiation of regulatory T cells, and mediates activation-induced cell death.

What are interleukins used for?

One of a group of related proteins made by leukocytes (white blood cells) and other cells in the body. Interleukins regulate immune responses. Interleukins made in the laboratory are used as biological response modifiers to boost the immune system in cancer therapy. An interleukin is a type of cytokine.

Does IL-2 cause inflammation?

IL-2 seems to prevent diabetes by inducing a repertoire of islet-reactive CD4+Foxp3+ Treg cells that suppress low-avidity islet-reactive effector cells, which thus escape negative selection in the thymus43. IL-2 also controls inflammation by inhibiting TH17 differentiation.

Is IL-2 a cytokine?

What are the side effects of IL-2?

Side effects of IL-2 can include flu-like symptoms such as chills, fever, fatigue, and confusion. Some have nausea, vomiting, or diarrhea. Many people develop low blood pressure, which can be treated with other medicines.

Do CD8 cells produce IL-2?

Abstract. IL-2 is an important cytokine that is capable of inducing both proliferation and apoptosis of activated T cells. CD4 T cells are thought to be the major producers of IL-2, but CD8 T cells also produce copious amounts of this cytokine.