What is an example of a privileged structure?

Many of the privileged structures in GPCR ligands are found in enzyme inhibitors. Examples include benzodiazepine-containing K-secretase inhibitors and farnesyl transferase inhibitors including the tricycle-based SCH-66336 and the tetrahydrobenzodiazepine.

What are privileged structures?

Privileged structures are molecular scaffolds with versatile binding properties, such that a single scaffold is able to provide potent and selective ligands for a range of different biological targets through modification of functional groups.

What is considered a natural product?

The broadest definition of a natural product is anything that is produced by life, and includes biotic materials (e.g. wood, silk), bio-based materials (e.g. bioplastics, cornstarch), bodily fluids (e.g. milk, plant exudates), and other natural materials that were once found in living organisms (e.g. soil, coal).

What is meant by privileged scaffold?

Abstract. Introduction: The term “privileged scaffold” was coined in 1988 and the strategy was to construct high-affinity ligands from core structures that can bind more than one receptor.

What is an example of a pharmacophore?

An example of a pharmacophore model of the benzodiazepine binding site on the GABAA receptor. White sticks represent the carbon atoms of the benzodiazepine diazepam, while green represents carbon atoms of the nonbenzodiazepine CGS-9896.

What is meant by the term Pharmacophore?

Pharmacophore is defined as “an ensemble of steric and electronic features that is necessary to ensure the optimal supramolecular interactions with a specific biologic target and to trigger (or block) its biologic response.”

Does the FDA regulate natural products?

The U.S. Food and Drug Administration’s (FDA’s) Center for Food Safety and Applied Nutrition regulates most natural products ranging from conventional foods to dietary supplements to cosmetics with regard to public health and enforcement.

What is meant by privileged scaffold Mcq?

What is meant by a privileged scaffold? a) A scaffold that is present in a wide range of drugs with different activities.

What is combinatorial green chemistry?

Combinatorial chemistry comprises chemical synthetic methods that make it possible to prepare a large number (tens to thousands or even millions) of compounds in a single process. These compound libraries can be made as mixtures, sets of individual compounds or chemical structures generated by computer software.

What means pharmacophore?

Pharmacophore is defined as “an ensemble of steric and electronic features that is necessary to ensure the optimal supramolecular interactions with a specific biologic target and to trigger (or block) its biologic response.” From: Pharmacology and Physiology for Anesthesia (Second Edition), 2019.