What MCP 3?

MCP3 in our study was also the only human CC chemokine that consistently chemoattracted neutrophils. These results suggest that MCP3 is a ligand that can bind and activate a broad range of target cells through receptors shared by other CC chemokines as well as its own receptor.

What is the name of CCL7?

Chemokine (C-C motif) ligand 7
Chemokine (C-C motif) ligand 7 (CCL7) is a small cytokine that was previously called monocyte-chemotactic protein 3 (MCP3).

What is the ligand for CCR2?

CCR2 is a G protein-coupled receptor, the ligands for which include the monocyte chemoattractant protein (MCP) family of chemokines (CCL2, CCL7, CCL8, etc.) (Boring et al., 1997).

Who has the CCR5 mutation?

Since the CCR5-delta 32 is tied primarily to the Eurasia region, the mutation has not been found in Africans, East Asians, or Amerindians. agoThrough their many invasions, the Vikings spread the allele from Scandanavia to Iceland, Russia, and central and southern Europe.

What is the role of CCL7?

CCL7 is a multipotent chemokine involved in anti-bacterial, anti-viral and anti-fungal immune responses. For example, CCL7-mediated stimulation of CCR2 chemokine receptors on monocytes is participating in the elimination of Listeria monocytogenes infections by the recruitment of monocytes and TNF/iNOS-producing dendritic cells (TipDCs).

What is the molecular weight of CCL7?

CCL7 can exist in four different glycotypes with a molecular weight 11, 13, 17 and 18 kDa in COS cells. CCL7 mediates effects on the immune cell types through binding to numerous receptors, including CCR1, CCR2, CCR3, CCR5, and CCR10. These receptors belongs to the G protein-coupled seven-transmembrane receptors.

How many introns are in the CCL7 gene?

The CCL7 gene has been given the locus symbol SCYA7. The gene consists of three exons and two introns. The first exon contains a 5′-untranslated region (5′-UTR), the information for the signal sequence (23 amino acids), and the mature protein’s first two amino acids.