Which of the following statins is the strongest inhibitor of HMG-CoA reductase?
Rosuvastatin is the most potent statin followed by atorvastatin. Statins also classify as lipophilic or hydrophilic. Lipophilic statins include simvastatin, lovastatin, and atorvastatin.
Which is the strongest statin?
Rosuvastatin and atorvastatin are the strongest statins because they have long half-lives. – Atorvastatin, simvastatin, and lovastatin are metabolized by the P450 cytochrome 3A4, which is inhibited by many other drugs and may thereby increase the risk of myopathy.
What is the difference between atorvastatin and pravastatin?
Are pravastatin and Lipitor the same? Both pravastatin and atorvastatin are medications used to reduce high levels of cholesterol. However, they are not the same. Atorvastatin is primarily metabolized by the CYP P450 enzyme system in the liver while pravastatin is broken down in the stomach.
What is equivalent to Lipitor?
NAPLEX Question of the Week: Statin Equivalencies
| Drug | Equivalent Dose (mg) by Intensity LDL reduction |
|---|---|
| Atorvastatin (Lipitor) | 10-20 |
| Simvastatin (Zocor) | 20-40 |
| Lovastatin (Mevacor) | 40-80 |
| Pravastatin (Pravachol) | 40-80 |
Is fenofibrate a HMG-CoA reductase inhibitor?
Fenofibrate treatment inhibits HMG-CoA reductase activity in mononuclear cells from hyperlipoproteinemic patients. Atherosclerosis.
Which single class drug is known to be most effective in reducing the major types of dyslipidemia?
Statins — Statins are one of the best-studied classes of medications and the most commonly used drugs for lowering LDL cholesterol. They are the most effective drugs for prevention of coronary heart disease, heart attack, stroke, and death.
What is the safest statin to take?
Simvastatin and pravastatin had the best safety profile, according to this review. Overall, the researchers found a 9 percent increased risk of type 2 diabetes in people taking statins.
What is the least potent statin?
Relative potency, therefore, appears to be a fundamental predictor of muscle-related AE risk, with fluvastatin, the least potent statin, an apparent exception (risk 74% vs rosuvastatin).
Is pravastatin better than other statins?
Compared to other statins, Pravachol (pravastatin) has fewer interactions with medicines. Pravachol (pravastatin) is less likely to cause muscle and kidney damage than other statin medicines. If you have liver problems, Pravachol (pravastatin) is the safest statin to use.
Which is more effective pravastatin or atorvastatin?
Thus, atorvastatin 80 mg/day causes a greater reduction in LDL-cholesterol than pravastatin 40 mg/day, and this is associated with a reduced progression of atheroma and reduced clinical events.
Is rosuvastatin more effective than atorvastatin?
Efficacy. At the end of the titration-to-goal period, rosuvastatin was significantly more effective than atorvastatin on the primary efficacy measure, reducing LDL-C by 52% compared with 46% in the atorvastatin group (p < 0.0001) (table 2).
What are HMG CoA reductase inhibitors?
Therapeutic Class Review HMG CoA Reductase Inhibitors Overview/Summary There are several classes of medications used to alter lipids including the hydroxymethylglutaryl coenzyme A (HMG CoA) reductase inhibitors (statins), fibric acid derivatives, bile acid sequestrants and nicotinic acid (niacin).
Are HMG-CoA reductase inhibitors effective in the treatment of hyperlipoproteinemia?
1 Department of Medicine, University of Ulm, Federal Republic of Germany. The HMG-CoA reductase inhibitors have been shown to cause marked reduction of cholesterol and offer a new and effective approach to treatment of hyperlipoproteinemia.
Are high dose hydroxymethylglutaryl coenzyme A reductase inhibitors safe?
Clinical trials demonstrating the safety and efficacy of the high dose hydroxymethylglutaryl coenzyme A reductase inhibitors (statins) in their Food and Drug Administration (FDA)-approved indications are outlined in Table 4.23-213 Statins are the most effective drugs available for lowering low density lipoprotein cholesterol (LDL-C).1
When to use HMG CoA reductase inhibitors in children?
Approved for use in children 10 to 17 years of age for the Renal dosage adjustment is required; for creatinine clearances <30 mL/minute, No dosage adjustment required. X Unknown; not re- commended. Therapeutic Class Review: HMG CoA reductase inhibitors Page 153 of 192 Copyright 2012 • Review Completed on 08/09/2012