Is desflurane more potent than sevoflurane?

Sevoflurane is more expensive than desflurane but is more potent, is rapidly acting and also has faster emergence and recovery.

What is the MAC value for desflurane?

Inhalation anesthetic agent Minimum alveolar concentration (MAC) value (1 MAC)*
Desflurane 6.6
Sevoflurane 1.8
Isoflurane 1.17
Halothane 0.75

What is the MAC for sevoflurane?

The minimum alveolar concentration (MAC) for sevoflurane required to prevent movement in response to surgical incision in healthy patients was 1.71 +/- 0.07% (SE).

Why is desflurane vaporizer different?

Desflurane’s vapor pressure, 681 mm Hg at sea level, is significantly higher than the other inhalational anesthetics and leads to a boiling point near room temperature. Its high vapor pressure and low boiling point led to the creation of a special desflurane vaporizer.

Is desflurane more potent than isoflurane?

Desflurane was only significantly more potent than halothane. The slopes of the curve fits for nitrous oxide and desflurane were significantly lower that those for sevoflurane, isoflurane, and halothane, but the nitrous oxide and desflurane slopes did not differ from each other.

What is MAC awake?

MAC-awake is defined as the anesthetic concentration needed to suppress a voluntary response to verbal command (i.e., eye-opening) in 50% of patients. [5] It is generally one-third of MAC for the inhaled anesthetic being used.

How does MAC relate to anesthetic potency?

The minimum alveolar concentration (MAC) of volatile agents is a term used to describe the potency of anesthetic vapors. It is defined as the concentration that prevents movement in response to skin incision in 50% of unpremedicated subjects studied at sea level (1 atmosphere), in 100% oxygen.

Why does desflurane need a heated vaporizer?

Desflurane’s unique characteristics (high volatility/moderate potency) require the use of a special vaporizer for proper utilization of this gas. Desflurane vaporizers are heated to 39 degrees C, which increases the vapor pressure in the sump to 1300mmHg, preventing the possibility of boiling in warm OR rooms.

What are the ISO‐MAC values for sevoflurane and desflurane?

Corresponding shifts are 0.86 and 1.16% for sevoflurane, and 3.15 and 4.22% for desflurane. The authors would like to thank colleagues who tested the iso‐MAC charts in clinical practice.

What is the Mac of desflurane in oxygen?

For example, in order to maintain a total MAC of 1.2 in an 80‐yr‐old patient using desflurane and nitrous oxide 67% in oxygen, it is clear from Fig. 3 that an increase in the FIO2 from 33 to 100%, associated with eliminating nitrous oxide, requires a compensatory three‐fold increase in the end‐expired concentration of desflurane, from 2 to 6.25%.

Is desflurane or sevoflurane better for MH patients?

Animal studies suggest that there is less risk with desflurane and sevoflurane (and possibly isoflurane) as compared to halothane; however, all potent volatile agents should be avoided in the MH-susceptible patient.

How do you find the age‐related Mac of sevoflurane?

To determine the total age‐related MAC, use the sevoflurane chart (Fig. 2) and first draw a vertical line corresponding to age 85 yr. Next, select the right‐hand scale corresponding to the use of nitrous oxide 67%, and draw a horizontal line through the sevoflurane 0.5% position. The two lines intersect on the 1.2 iso‐MAC curve.