What does E339K mutation in the glucokinase gene refer to?

Abstract. Human glucokinase (GK) plays an important role in glucose homeostasis. An E339K mutation in GK was recently found to be associated with hyperglycemia. It showed lower enzyme activity and impaired protein stability compared to the wild-type enzyme.

What is the glucokinase GCK gene and what is its role in diabetes?

What is Glucokinase (GCK)? Glucokinase (GCK) is a gene which plays an important role in recognising how high the blood glucose is in the body. It acts as the “glucose sensor” for the pancreas, so that when the blood glucose rises, the amount of insulin produced also increases.

What is glucokinase gene?

The GCK gene provides instructions for making a protein called glucokinase. This protein plays an important role in the breakdown of sugars (particularly glucose) in the body. Glucokinase is primarily found in the liver and in beta cells in the pancreas.

What is glucokinase inhibited by?

Glucokinase is inhibited in the postabsorptive state by sequestration in the nucleus bound to GKRP, and it is activated postprandially by portal hyperglycemia and fructose through dissociation from GKRP, translocation to the cytoplasm, and binding to PFK2/FBP2.

Which of the following factors is important for the glucose sensing action of glucokinase in liver?

Insulin is by far the most important of the hormones that have direct or indirect effects on glucokinase expression and activity in the liver. Insulin appears to affect both glucokinase transcription and activity through multiple direct and indirect pathways.

Which of the following is a characteristic of glucokinase?

Metabolism in Surgical Patients Glucokinase is an isoform of hexokinase with two peculiarities: first, in contrast to hexokinase, the product of its reaction, glucose-6-phosphate, does not inhibit glucokinase, and second, it has a low binding affinity for glucose compared to the other hexokinase enzymes.

Is glucokinase regulated by insulin?

Glucokinase is very important in the regulation of insulin secretion and has been known as the pancreatic beta-cell sensor. Mutations in the gene encoding glucokinase can cause both hyperglycemia and hypoglycemia because of its central role in the regulation of insulin release.