What is sarcomatous degeneration?

Sarcomatous degeneration is a rare but serious complication of Paget’s disease of bone with an incidence of 0.1–1%. The true aetiology of Paget’s sarcoma remains unclear. The most common sites for Paget’s sarcoma are femur, humerus, pelvis, skull and tibia.

What is Sarcomatous?

Listen to pronunciation. (sar-KOH-muh) A type of cancer that begins in bone or in the soft tissues of the body, including cartilage, fat, muscle, blood vessels, fibrous tissue, or other connective or supportive tissue. Different types of sarcoma are based on where the cancer forms.

What happens to bones in Paget’s disease?

Paget’s (PAJ-its) disease of bone interferes with your body’s normal recycling process, in which new bone tissue gradually replaces old bone tissue. Over time, bones can become fragile and misshapen. The pelvis, skull, spine and legs are most commonly affected.

What is Sarcomatous change?

Sarcomatoid transformation in a carcinoma is a rare event but frequently associated with advanced disease stage, aggressive clinical behavior and dismal prognosis. It’s likely a result of stepwise gene mutations in pluripotent stem cell and involves the epithelial to mesenchymal transition (EMT).

How is Paget’s disease of bone diagnosed?

X-rays. The first indication of Paget’s disease of bone is often abnormalities found on X-rays done for other reasons. X-ray images of your bones can show areas of bone breakdown, enlargement of the bone and deformities that are characteristic of the disease, such as bowing of your long bones. Bone scan.

What is difference between sarcoma and carcinoma?

A carcinoma forms in the skin or tissue cells that line the body’s internal organs, such as the kidneys and liver. A sarcoma grows in the body’s connective tissue cells, which include fat, blood vessels, nerves, bones, muscles, deep skin tissues and cartilage.