What is t1 2 in pharmacology?
Half-life (t1/2) refers to the time required for plasma concentration of a drug to decrease by 50%. t1/2 is dependent on the rate constant (k), which is related to Vd & clearance (CL).
What is Cmax and tmax in pharmacokinetics?
The three classical pharmacokinetic parameters used to assess bioequivalence, AUC (total area from zero to infinity), Cmax (peak plasma concentration), and tmax (time to reach Cmax), are suitable to determine the extent and rate of absorption of immediate-release drug products.
What is VZ F?
Vz/F. Apparent volume of distribution during terminal phase (Vz/F) after non-intravenous administration can be calculated as (CL/F)/ Ke.
What does Cmax mean in pharmacology?
Cmax is the highest concentration of a drug in the blood, cerebrospinal fluid, or target organ after a dose is given. Related Term(s)
What is CSS in pharmacokinetics?
Css = concentration of drug in plasma at steady state. This works well for IV infusion. For repeated bolus dosing, the OSCILLATIONS in concentration that give rise to peaks and troughs.
What is serum halflife?
This is the period of time required for the concentration or amount of drug in the body to be reduced by one-half. We usually consider the half life of a drug in relation to the amount of the drug in plasma. A drug’s plasma half-life depends on how quickly the drug is eliminated from the plasma.
What is the relation between Cmax and Tmax?
Cmax is the opposite of Cmin, which is the minimum (or trough) concentration that a drug achieves after dosing. The related pharmacokinetic parameter tmax is the time at which the Cmax is observed.
What is AUC of a drug?
In pharmacology, the area under the plot of plasma concentration of a drug versus time after dosage (called “area under the curve” or AUC) gives insight into the extent of exposure to a drug and its clearance rate from the body.
What is Tlag pharmacokinetics?
Lag time in pharmacokinetics corresponds to the finite time taken for a drug to appear in systemic circulation following extravascular administration.
What is VSS in pharmacokinetics?
Pharmacokinetics – Concepts and Applications. Contributor © Minh Vo. C- Steady-state volume of distribution (Vss) Steady state volume of distribution (Vss) reflects the actual blood and tissue volume into which a drug is distributed and the relative binding of drug to protein in these spaces.
What is AUC and Cmax?
In bioequivalence studies, the maximum concentration (Cmax) is shown to reflect not only the rate but also the extent of absorption. Cmax is highly correlated with the area under the curve (AUC) contrasting blood concentration with time.
What is AUC in bioavailability?
In the field of pharmacokinetics, the area under the curve (AUC) is the definite integral of a curve that describes the variation of a drug concentration in blood plasma as a function of time (this can be done using liquid chromatography–mass spectrometry).