What is the reverse cholesterol transport mechanism?
Reverse cholesterol transport is a mechanism by which the body removes excess cholesterol from peripheral tissues and delivers them to the liver, where it will be redistributed to other tissues or removed from the body by the gallbladder. The main lipoprotein involved in this process is the HDL-c.
What is the function of CETP?
CETP is an enzyme responsible for moving cholesterol esters and triglycerides between VLDL, LDL, and HDL. Lower CETP levels promote HDL formation. Since higher HDL levels are associated with decreased risk of atherosclerosis, the activity of CETP is thought to promote development of the disease by reducing HDL levels.
Which plays the largest role in reverse cholesterol transport?
HDL plays a critical role in reverse cholesterol transport, from peripheral tissues to the liver (Figure 6, Animated). The major lipoprotein components in HDL are ApoAI, ApoCII, and ApoE.
Which lipoprotein is involved in reverse cholesterol transport?
Reverse Cholesterol Transport (RCT) The main lipoprotein involved in this process is the HDL-c.
What is the function of HDL during reverse cholesterol transport?
The surface of HDL is available to accept more free cholesterol, forming mature spherical HDL particles. In addition, HDL functions as a chaperone for the transfer of cholesterol ester to the liver. The scavenger receptor class B1 (SR-B1) modulates the selective uptake of HDL cholesterol ester by hepatocytes.
What is the CETP low cholesterol mutation?
Many mutations in CETP gene, including D442G mutation, result in reduced CETP activity, which consequently increases plasma HDL cholesterol level. This study showed that D442G mutation is associated with increased plasma HDL cholesterol level by 12% in Korean women.
What is the role of LCAT in cholesterol metabolism?
The LCAT enzyme helps transport cholesterol out of the blood and tissues by a process called cholesterol esterification. This process results in a form of cholesterol that is more efficiently carried by molecules called lipoproteins, which transport the cholesterol to the liver.
Which type of cholesterol and apolipoprotein is associated with reverse cholesterol transport?
Reverse cholesterol transport is a multi-step process resulting in the net movement of cholesterol from peripheral tissues back to the liver via the plasma compartment. Cellular cholesterol efflux is mediated by HDL, acting in conjunction with the cholesterol esterifying enzyme, lecithin: cholesterol acyltransferase.
What type of mutation is CETP?
Abstract. Cholesteryl ester transfer protein (CETP) is thought to regulate plasma HDL. Patients with CETP deficiency caused by mutation of the CETP gene [D442G; a missense mutation (Asp442→Gly)] have been reported to show high plasma HDL levels.
What causes Tangier disease?
Causes. Mutations in the ABCA1 gene cause Tangier disease. This gene provides instructions for making a protein that releases cholesterol and phospholipids from cells. These substances are used to make HDL , which transports them to the liver .