Do cancer cells feed on glutamine?
One reason that cancer cells rely on high levels of exogenous glutamine is because glutamine can be used to fuel the TCA cycle through α-ketoglutarate to allow its further oxidation . It was shown that glutamine depletion reduces the NADH/NAD+ ratio, which inhibits oxygen consumption and ATP production .
Does glutamine increase cancer?
This low glutamine-induced histone hypermethylation promoted melanoma tumour dedifferentiation and resistance to BRAF inhibitors. These results suggest that low glutamine in the tumour microenvironment, similar to hypoxia, may drive cancer progression and augment resistance to treatment via epigenetic regulation.
What is the role of glutamine in cancer?
Glutamine is an extremely versatile nutrient that contributes to many aspects of intermediary metabolism in cancer cells. It is particularly important in the formation of the macromolecules required for cell proliferation and resistance to oxidative stress.
What cancers feed off L-glutamine?
Cells are dependent on glutamine in so many ways. Mutations in the genes IDH1 and IDH2, which also change how glutamine products are used in a cell, are common in certain types of brain cancer and leukemia. This high demand for glutamine means that supplies of it inside of a tumor are often quite low.
What foods have glutamine?
Good sources of L-glutamine can be found in certain foods, including:
What is cancer cell metabolism?
Cancer cell metabolism is a direct result of the modulation of intracellular signaling pathways that are disrupted by mutated oncogenes and tumor-suppressor genes. Mutated oncogenic genes can directly initiate cancer cell metabolism. Similarly, mutated metabolic enzymes can facilitate malignant transformation.