How is pigment epithelial detachment treated?

Treatment. Currently no treatment for serous PED is proven effective, nor are recommendations for treatment guidelines established. Several strategies, however, have being used to treat vascularized PEDs, including laser photocoagulation, photodynamic therapy (PDT), intravitreal steroids and anti-VEGF therapy.

Does pigment epithelial detachment cause blindness?

In AMD, PEDs are important markers of disease severity, risk for progression, and vision loss. PEDs are seen in up to 62% of eyes with advanced AMD,4 and approximately 50% of patients with newly diagnosed PEDs will experience significant visual loss (>3 lines) one year from diagnosis.

What causes retinal pigment epithelial detachment?

Tears of the retinal pigment epithelium (RPE) are most commonly associated with vascularised RPE detachment due to age-related macular degeneration (AMD), and they usually involve a deleterious loss in visual acuity.

Does retinal pigment epithelium regenerate?

The retinal pigment epithelium (RPE) is an ocular tissue critical for maintaining a functional visual system, and death of RPE cells leads to blindness. Humans and other mammals are unable to regenerate the RPE, so vision loss is irreversible.

What is a serous PED?

Serous PED is defined as an area of sharply demarcated, dome-shaped serous elevation of the retinal pigment epithelium (RPE). The histopathology of serous PED is consistent with the detachment of the RPE basement membrane, along with the overlying RPE from the remaining Bruch’s membrane due to accumulation of fluid(1).

What is the treatment for central serous retinopathy?

The most common treatment for central serous retinopathy is called photodynamic therapy. This uses a special laser called a cold laser to treat the fluid build-up under the retina when central serous retinopathy occurs or recurs.

What is serous detachment of retinal pigment epithelium?

Serous retinal pigment epithelium detachment (PED) is one of the symptoms of age-related macular degeneration (AMD) and is detected in about 10% of patients with the exudative form of AMD [1-3]. Haab was the first researcher to clinically describe serous PED [2].

How successful is ERM surgery?

Abstract. Purpose: Surgery has been successful in removing epiretinal membranes (ERM) from the macula, allowing some improvement in vision in 80-90% of patients; however, complications are relatively frequent.

What is ERM surgery?

The surgery for ERMs is called a vitrectomy. During a vitrectomy, the surgeon will make tiny cuts in the affected eye and remove the fluid from inside the eye. The surgeon will then hold and gently peel the epiretinal membrane from the retina and replace the fluid in the eye.

What is fibrovascular PED?

Clinically, a PED appears as a smooth dome-shaped subretinal elevation on fundoscopy and may be associated with other nAMD findings such as drusen, subretinal fluid, hemorrhage, or overlying RPE hyperplasia. Fibrovascular PED in type 1 CNV appears as an irregular RPE elevation with or without serous exudate.

What is Drusenoid pigment epithelial detachment?

Drusenoid pigment epithelial detachments (PEDs) are characterized by displacement of the retinal pigment epithelium (RPE) away from Bruch’s membrane (BrM) and are due to enlargement and/or coalescence of soft drusen.

What are retinal pigment epithelial detaches?

Retinal pigment epithelial detachments (PEDs) are characterized by separation between the RPE and the inner most aspect of Bruch’s membrane. The space created by this separation is occupied by blood, serous exudate, drusenoid material, fibrovascular tissue or a combination.

What is the treatment for pigment epithelial detachment in neovascular age-related macular degeneration?

Sarraf D, London NJ, Khurana RN, et al. Ranibizumab treatment for pigment epithelial detachment secondary to neovascular age-related macular degeneration: post hoc analysis of the HARBOR study. Ophthalmology. 2016;123 (10):2213-2224.

Does pigment epithelial detachment height predict intravitreal bevacizumab injection-associated retinal tears?

Chan CK, Abraham P, Meyer CH, et al. Optical coherence tomography-measured pigment epithelial detachment height as a predictor for retinal pigment epithelial tears associated with intravitreal bevacizumab injections. Retina. 2010;30 (2):203-211.

What is pigment epithelial Detachment (PED)?

Pigment epithelial detachment (PED) means that there is fluid beneath the retinal pigment epithelium (RPE) which is the layer of cells beneath the retina. PED has many causes but the most common are age-related macular degeneration and central serous choroidopathy. Treatment depends on the location, size and cause of the PED.