What are the possible sources of benzo a pyrene you might encounter in your daily life?

This chemical results from burning plants, wood, coal, and operating cars, trucks and other vehicles. The major indoor sources of benzo(a)pyrene in the air are wood-burning fireplaces and stoves, and tobacco smoking. There is no known industry production or use of benzo(a)pyrene.

What does benzopyrene do to your body?

It is found in car exhaust, smoke from wood fires, tobacco, oil and gas products, charred or grilled foods, and other sources. It may also be found in water and soil. Benzo(a)pyrene can cause a skin rash, a burning feeling, skin color changes, warts, and bronchitis. It may also cause cancer.

Is benzo a pyrene toxic?

Benzo[a]pyrene is a complete carcinogen and also an initiator of skin tumors (IARC, 1973; EPA, 1991). Benzo[a]pyrene has also been reported to induce tumors in animals when administered by other routes, such as intravenous, intraperitoneal, subcutaneous, intrapulmonary, and transplacental.

Is benzo a pyrene mutagenic?

Introduction. Benzo[a]pyrene (B[a]P) is a potent mutagen/carcinogen, and an example of a polycyclic aromatic hydrocarbon (PAH), a class of substances produced by incomplete combustion, which are found ubiquitously in the environment (1–7).

Why is benzo a pyrene carcinogenic?

The substance with the formula C20H12 is one of the benzopyrenes, formed by a benzene ring fused to pyrene. Its diol epoxide metabolites (more commonly known as BPDE) react with and bind to DNA, resulting in mutations and eventually cancer. It is listed as a Group 1 carcinogen by the IARC.

Is benzo a pyrene carcinogen?

Benzo[a]pyrene (B[a]P), the prototype of polycyclic aromatic hydrocarbons, exhibits genotoxic and carcinogenic effects and it is a human carcinogen according to the International Agency for Research on Cancer.

Why is benzo a pyrene a carcinogen?

How does benzo a pyrene cause mutations?

Abstract. Benzo[a]pyrene (BaP), a polycyclic aromatic hydrocarbon, is the major cause of lung cancer. BaP forms covalent DNA adducts after metabolic activation and induces mutations.

How does benzopyrene cause mutation?

Benzo[a]pyrene (BaP), a polycyclic aromatic hydrocarbon, is the major cause of lung cancer. BaP forms covalent DNA adducts after metabolic activation and induces mutations.

Is benzo a pyrene in gasoline?

On average 36 percent of the benzo[a]pyrene in an automobile’s exhaust gas comes from the benzo[a]pyrene originally in the gasoline. Between 0.1 and 0.2 percent of the benzo[a]pyrene in the gasoline survives the combustion process and is recovered from the exhaust; 5 percent accumulates in the crankcase oil.

How does benzo a pyrene damage DNA?

Within a lung cell, benzo[a]pyrene is converted to an epoxide. The epoxide reacts readily with guanine (G) positions of the DNA helix. If not corrected by the cell’s DNA repair mechanism, this guanine “adduct†is misread as a thymine by the DNA polymerase that copies chromosomes during replication.