What is Monotropic and Enantiotropic?
The key difference between enantiotropic and monotropic is that the term enantiotropic refers to the state of having different polymorphic states that are stable at different temperatures, whereas the terms monotropic refers to the state of having only one polymorph that is stable at all the reasonable temperatures.
What is Enantiotropic polymorph?
An enantiotrope is a polymorph that undergoes a reversible transformation into another polymorph at atmospheric pressure. If you’re not familiar with the concept of reversibility you may want to read up on entropy, spontaneity, and the 2nd law of thermodynamics.
What is Enantiotropic system?
In an enantiotropic system, the metastable form at room temperature can be obtained by heating the stable form above the transition temperature. In a monotropic system, the stable form at room temperature can be obtained by heating the metastable form at any temperature.
What is Enantiotropic transition?
For enantiotropic polymorphs, the transition temperature is of great importance since it defines the temperature at which the stability relationship between the two forms becomes inverted. There are several methods currently available to experimentally determine or estimate this value.
What do you mean by pseudo polymorphism?
Pseudo-polymorphism is also a known phenomenon in which two compounds exhibit different crystalline structures, of which one is the host of solvent molecules. Some reaction conditions such as different temperatures,3 solvent,4 pressure5 or presence of impurities or additives6 can result in the formation of polymorphs.
What is pseudo polymorphism?
Pseudopolymorphism is the phenomenon wherein a compound is obtained in crystalline forms that differ in the nature or stoichiometry of included solvent molecules. 1 This subject has not been treated systematically though it is perceived to be of general importance, for example in the pharmaceutical in- dustry.
What does Polymorphing mean?
noun. Biology. an organism having more than one form or type as a result of discontinuous variation. Crystallography. any of the crystal forms assumed by a substance that exhibits polymorphism.
What is Solvate form?
Solvates or pseudopolymorphs are different crystalline forms of the same compound with association of solvent within the crystal lattice in a stoichiometric or non-stoichiometric ratio and are quite different from the polymorphs of the same drug molecule (4).
What is polymorphism and amorphous?
Amorphous polymorphism☆ Recent studies of amorphous solid materials have revealed the possibility that more than one distinct amorphous phase may be formed from the same substance. In analogy with the phenomenon of crystalline polymorphism, this behavior has been termed “amorphous polymorphism”.
What is polymorphism example?
A real-life example of polymorphism, a person at the same time can have different characteristics. Like a man at the same time is a father, a husband, an employee. So the same person posses different behavior in different situations. This is called polymorphism.
What is transient polymorphism?
Transient Polymorphisms Occurs when there are two alleles in the gene pool and one allele is gradually replacing the other. This is due to a strong environmental pressure causing directional selection to eliminate one allele from the gene pool.
What is a polymorphic person?
adjective. having or occurring in several distinct forms. “man is both polymorphic and polytypic” synonyms: polymorphous multiform. occurring in or having many forms or shapes or appearances.