What is the role of voltage gated potassium channels?
Voltage-gated potassium ion channels (Kv) play an important role in a variety of cellular processes, including the functioning of excitable cells, regulation of apoptosis, cell growth and differentiation, the release of neurotransmitters and hormones, maintenance of cardiac activity, etc.
What is voltage gated potassium channel antibody syndrome?
Background Voltage-gated potassium channel (VGKC)-complex antibodies can be associated with a range of immunotherapy-responsive clinical presentations including limbic encephalitis, Morvan’s syndrome and acquired neuromyotonia. However, there are patients with positive levels in whom the significance is uncertain.
What happens if voltage-gated potassium channels are blocked?
These drugs bind to and block the potassium channels that are responsible for phase 3 repolarization. Therefore, blocking these channels slows (delays) repolarization, which leads to an increase in action potential duration and an increase in the effective refractory period (ERP).
What happens if voltage-gated sodium channels are blocked?
Blocking voltage-gated sodium channels (NaV) will prevent action potential initiation and conduction and therefore prevent sensory communication between the airways and brainstem. In so doing, they would be expected to inhibit evoked cough independently of the nature of the stimulus and underlying pathology.
What are some neurological Channelopathies associated with voltage dependent K+ channels?
These include acquired neuromyotonia, episodic ataxia type‐1, hereditary deafness syndromes, benign familial neonatal convulsions and hypokalaemic periodic paralysis.
What is Morvans syndrome?
Morvan syndrome (MoS) is a rare autoimmune syndrome associated with antibodies against two kinds of potassium channel proteins, contactin associated protein-like 2 (CASPR2) and leucine-rich glioma inactivated protein 1 (LGI1). MoS patients with only LGI1-antibody seropositivity have rarely been reported.
Can you recover from limbic encephalitis?
Initial recovery may be rapid but usually falls short of complete. Further recovery takes place more slowly over a period of months, even years. People are different. No two cases of encephalitis will have an identical outcome and people recover at different paces.
What happens if potassium channels Cannot open?
When there is a problem to Potassium K+ channel happened, it will lead to Early After Depolarisation (EAD) symptom to happen that is mechanism on how a long QT syndrome happened. LONG QT syndrome have a prolonged QT interval because depolarisation phase has been prolonged too.