Why is fluorine-18 useful?
Fluorine-18 This radioactive isotope of fluorine emits positrons. F-18 can be used to make a radioactive form of glucose that is readily taken up by cancer cells and other cells. Using nuclear imaging it can be used to detect tumours map brain function and detect other illness.
What are the features of fluorine-18?
Fluorine-18 (18F) is a fluorine radioisotope which is an important source of positrons. It has a mass of 18.0009380(6) u and its half-life is 109.771(20) minutes. It decays by positron emission 96% of the time and electron capture 4% of the time. Both modes of decay yield stable oxygen-18.
Why is fluorine-18 the most used positron emitter?
Because of its short half-life and positron emission, 18F is widely used in molecular imaging of biological and biochemical processes, including early detection of many diseases and assessment of treatment response by positron emission tomography (PET) [24-34].
What type of radiation is emitted by fluorine-18?
Fluorine F 18 decays by positron ,(β+) emission and has a half-life of 109.7 minutes. The principal photons useful for diagnostic imaging are the 511 keV gamma photons, resulting from the interaction of the emitted positron with an electron (Table 1).
How is F-18 produced?
In order to emit positron, fluorine-18 (18F) isotope is prepared from water enriched with the 18O isotope using high energy protons by a cyclotron. A cyclotron is a particle accelerator. These particles are then focused onto a target O18 and the bombardment causes the production of the desired radioisotope i.e. F18.
What characteristic of F 18 FDG makes it useful in tumor imaging?
Fluorine F 18 decays by positron (β+) emission and has a half-life of 109.7 minutes. The principal photons useful for diagnostic imaging are the 511 keV gamma photons, resulting from the interaction of the emitted positron with an electron (Table 1).
What does F18 decay to?
PET radionuclides decay by positron emission, and in the case of fluorine-18, it decays to oxygen-18 releasing a neutrino (ν) and a positron (β+).
What are 5 things fluorine is used for?
It is found as fluoride in toothpaste and drinking water, in Teflon (polytetrafluoroethylene), drugs including the chemotherapeutic drug 5-fluorouracil, and etchant hydrofluoric acid. It is used in refrigerants (chlorofluorocarbons or CFCs), propellants, and for the enrichment of uranium by UF6 gas.
How was fluorine 18 discovered?
The noble gases, or Group 18 (VIIIA), also known as the inert gases, generally do not react with other elements. Fluorine was discovered in 1886 by French chemist Henri Moissan (1852-1907). Moissan collected the gas by passing an electric current through one of its compounds, hydrogen fluoride (H 2 F 2 ).
Is fluorine-18 proton rich?
The nucleus of fluorine-18 is unstable as it is proton rich, as such; a proton converts to a neutron and emits a positron and neutrino. A positron is an antimatter particle which is similar to an electron but has a positive charge.
What is Fluorine-18 used for?
Fluorine-18 is one of the early tracers used in positron emission tomography (PET), having been in use since the 1960s.
What is the half life of fluorine 18 FDG?
Fluorine-18 Fluorodeoxyglucose. F-18 FDG is a marker of myocardial glucose metabolism. It has a physical half-life of 1.8 hours (110 minutes). Only 1% to 4% of the injected dose is trapped in the myocardium; however, the target-to-background ratio is high.
Why is Fluorine-18 used in PET imaging?
Fluorine-18 is one of the most frequently used radioisotopes in PET imaging because of its favorable decay characteristics and physical properties.
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