What is IRF3 gene?
IRF3 (Interferon Regulatory Factor 3) is a Protein Coding gene. Diseases associated with IRF3 include Encephalopathy, Acute, Infection-Induced 7 and Encephalopathy, Acute, Infection-Induced 10. Among its related pathways are Diseases associated with the TLR signaling cascade and Toll-Like receptor Signaling Pathways.
What is the role of IRF3?
IFN regulatory factor 3 (IRF3) is a transcription regulator of cellular responses in many cell types that is known to be essential for innate immunity.
What activates IRF3?
IRF3 is a transcription factor that controls multiple IFN-inducing pathways, including the TLR3 pathway, which can be triggered by dsRNA, and the pathways triggered by other RNA and DNA sensors. IRF3 is normally activated by TBK1 and/or IKKε kinases.
Is IRF3 an ISG?
Viral infection activates interferon regulatory factor 3 (IRF3), a cofactor for the induction of interferon-stimulated genes (ISGs).
Is IRF3 a cytokine?
We have demonstrated here that IRF3 is involved in the early expression of IL-6 in response to TMEV, which is a cytokine that helps control viral replication but which are also involved in CNS pathology.
What activates IRF7?
IRF7 is activated by pathogenic nuclei acids through pathways mediated by TLR3, -7 and -9, RIG-I and likely DNA-dependent activator of IRF and IFI16, as well as by TLR2-mediated signaling pathway.
What is IRF3 5D?
IRF3(5D) is the constitutive active mutant of IRF3. 19,36,37 The seven phosphorylation sites in RD can be phosphorylated by TBK1 or IKK”. The putative proline-dependent phosphorylation sites are Thr3, Ser123, Ser170, Thr180 and Ser339.
What stimulates interferon production?
Interferons (IFNs) are proteins produced by a variety of cells in the inflammatory response to infections. Their production is triggered by the immune system in response to pathogens or cytokines.