What do methyl CpG binding proteins do?

Classical methyl-CpG binding proteins contain the conserved DNA binding motif methyl-cytosine binding domain (MBD), which preferentially binds to methylated CpG dinucleotides. These proteins serve as transcriptional repressors, mediating gene silencing via DNA cytosine methylation.

What does binding protein mean?

A binding protein is any protein that acts as an agent to bind two or more molecules together. Examples include: DNA-binding protein. Single-strand binding protein. Telomere-binding protein.

How does protein binding affect drug distribution?

Protein-binding may affect drug activity in one of two ways: either by changing the effective concentration of the drug at its site of action or by changing the rate at which the drug is eliminated, thus affecting the length of time for which effective concentrations are maintained.

What CpG means?

Consumer packaged goods (CPGs) is an industry term for merchandise that customers use up and replace on a frequent basis. Examples of consumer packaged goods include food, beverages, cosmetics, and cleaning products.

What causes CpG island methylation?

The reason for methylation to be almost exclusive to CpG dinucleotides is the symmetry of the dinucleotide. This allows for preservation during cell division and is a hallmark for epigenetic modifications.

What does CpG Island stand for?

CpG islands (CGIs) are regions of the genome that contain a large number of CpG dinucleotide repeats. In mammalian genomes, CpG islands usually extend for 300–3000 base pairs. They are located within and close to sites of about 40% of mammalian gene promoters.

What does CpG stand for in genetics?

CpG: In genetics, a site where cytosine (C) lies next to guanine (G) in the DNA sequence. (The p indicates that C and G are connected by a phosphodiester bond.)

What does the word methyl-CpG-binding protein 2 mean?

Here are all the possible meanings and translations of the word methyl-cpg-binding protein 2. A DNA-binding protein that interacts with methylated CPG ISLANDS. It plays a role in repressing GENETIC TRANSCRIPTION and is frequently mutated in RETT SYNDROME.

What are the different types of methyl-CpG-binding proteins?

In this chapter, we focus on the three major families of methyl-CpG-binding proteins: the MBD protein family, Kaiso and Kaiso-like proteins, and SRA domain proteins.

What is methyl-CpG-binding protein (MECP2)?

Kimura H, Shiota K (2003) Methyl-CpG-binding protein, MeCP2, is a target molecule for maintenance DNA methyltransferase, Dnmt1. J Biol Chem 278:4806–4812 [ PubMed] Klose RJ, Bird AP (2004) MeCP2 behaves as an elongated monomer that does not stably associate with the Sin3a chromatin remodeling complex. J Biol Chem 279:46490–46496 [ PubMed]

How is MBD1 recruited to both methylated and nonmethylated CPGs?

Jorgensen HF, Ben-Porath I, Bird AP (2004) Mbd1 is recruited to both methylated and nonmethylated CpGs via distinct DNA binding domains. Mol Cell Biol 24:3387–3395 [ PMC free article] [ PubMed]