What is a high alkaloid content for kratom?
Typical potency The total alkaloid concentration in dried leaves ranges from 0.5–1.5 %. In Thai varieties, mitragynine is the most abundant component (up to 66 % of total alkaloids) while 7-hydroxymitragynine is a minor constituent (up to 2 % of total alkaloid content).
What medications does kratom interact with?
To date several case studies of drug interactions with Kratom have been reported that relate to its CNS depressant effects. Both additive and synergistic effects are observed if Kratom is used with benzodiazepines, barbiturates, alcohol, opioids, antidepressants, anxiolytics, and other CNS-active drugs .
What is the half life of mitragynine?
The half-life is 3.5 hours for mitragynine and 2.5 hours for 7-a-hydroxymitragynine. Withdrawal symptoms similar to those associated with opioid withdrawal have been reported, though less severe and shorter in duration.
How hard is kratom on the liver?
The onset of injury is usually within 1 to 8 weeks of starting regular use of kratom powder or tablets, with symptoms of fatigue, nausea, pruritus and dark urine followed by jaundice. The pattern of liver injury is typically cholestatic or mixed, and it can be severe with serum bilirubin levels rising above 20 mg/dL.
What is a high dose of kratom?
A higher dose is usually above 5 grams. Over 10 grams, any dosage is exceptionally high, and it may increase the risk of side effects. The general dosage guide for Kratom is as follows. Beginner dose: 1 gram. Low dose: 1grams -2 grams. Moderate dose: 3 grams-5 grams. High dose: 5 grams and more.
What is kratom?
What is Kratom? Kratom ( Mitragyna speciosa) is a tropical evergreen tree from Southeast Asia and is native to Thailand, Malaysia, Indonesia and Papua New Guinea. Kratom, the original name used in Thailand, is a member of the Rubiaceae family. Other members of the Rubiaceae family include coffee and gardenia.
Is kratom safe and natural?
The fact that kratom is derived from a plant should not lead consumers to be believe it 100% safe and “all-natural”. While certainly not all botanicals have dangerous properties, drugs with dangerous effects can come from botanicals, for example, heroin (opium poppy), cocaine (coca leaves), and nicotine (tobacco).
What is the best kratom for energy and focus?
When it comes to energy and focus, white-veined kratom is considered the best option. Lower doses of kratom are also great for facilitating a desire to socialize with friends similar to alcohol. It elicits feelings of euphoria, talkativeness, and an overall pleasant mood, without the harmful health effects of alcohol.