How much is an overdose of Depakote?

200 – 400mg/kg: moderate toxicity, i.e. CNS depression. 400 — 1000 mg/kg: severe toxicity, i.e. Coma. >1g/kg: potentially life threatening, i.e. profound coma, multi-organ toxicity including hypotension, metabolic (lactic) acidosis, cerebral oedema, biochemical abnormalities, bone marrow suppression.

Is 1500 mg of Depakote too much?

Although doses other than 1000 mg once daily of Depakote ER have not been evaluated in patients with migraine, the effective dose range of Depakote (divalproex sodium delayed-release tablets) in these patients is 500-1000 mg/day.

Is 750 mg of Depakote a lot?

Depakote tablets are administered orally. The recommended initial dose is 750 mg daily in divided doses. The dose should be increased as rapidly as possible to achieve the lowest therapeutic dose which produces the desired clinical effect or the desired range of plasma concentrations.

Can Depakote ER be taken twice a day?

The “ER” in Depakote ER stands for Extended Release. Available in two strengths, Depakote ER contains the same active ingredient as Depakote Delayed-Release Tablets but it is designed to slowly deliver the medication over a 24-hour period. This means that Depakote ER only has to be taken once a day.

How is Depakote toxicity treated?

Treatment / Management Therapy for patients with valproate toxicity is mainly supportive and includes initial stabilization and resuscitation. Measures include maintenance of airway, breathing, and circulation. Establish early IV access as intravenous fluid administration for the patients presenting with hypotension.

Can Depakote ER be given twice daily?

How much Depakote can you take in a day?

Adults—At first, 250 milligrams (mg) 2 times a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 1000 mg per day. Children—Use and dose must be determined by your doctor.

Is Depakote a high risk medication?

Taking Depakote has been linked to some serious and even deadly side effects. Liver damage is one of the side effects that may be fatal. This is especially true in children under 2. This risk is highest in the first months of taking the medication.

What can happen if you take too much Depakote?

Have liver disease,such as from long-term alcohol use,HIV,or viral hepatitis

  • Drink alcohol and take medicines at the same time
  • Are older
  • Are a woman
  • Use long-acting or extended release medicines
  • Take multiple medicines that contain acetaminophen. There are many medicines both over-the-counter and prescription with acetaminophen.
  • Use herbal supplements
  • Why is Depakote so expensive?

    Eslicarbazepine acetate (Aptiom) Brand-name Aptiom costs$1,010.09 for thirty 400-mg tablets.

  • Carbamazepine ER (Carbatrol) Brand-name Carbatrol costs$113.32 for sixty 200-mg tablets.
  • Valproic acid (Depakene) Brand-name Depakene costs$450.30 for ninety 250-mg tablets.
  • What are the side effects, if any, when stopping Depakote?


  • dizziness
  • depression
  • irritability
  • anxiety
  • How much Depakote will cause you to overdose?

    Re: Depakote Overdose. Wow I definitely believe you can OD on a medicine given at 30,000mg! Are you sure it isn’t 3,000 mg and you misheard him? I mean the high dosage for Depakote is normal but he should be doing blood work to check your valpuric acid levels. I am on 1,000 mg and I am at a perfect place right now.