What does a positive ribonucleoprotein mean?
A positive result for RNP antibodies is consistent with a connective tissue disease.
What causes high RNP?
Antibodies to ribonucleoprotein, RNP, are found often in very high levels in patients with a variety of systemic rheumatic diseases, including SLE, progressive systemic sclerosis and Mixed Connective Tissue Disease, a distinct disease entity with overlapping clinical features of SLE, scleroderma, polymyositis and …
What is ribonucleoprotein antibody?
The Sm and nuclear ribonucleoprotein (RNP) antigens are a particulate complex composed of small nuclear RNAs (U-RNAs) and proteins. This complex has also been referred to as extractable nuclear antigens (ENA), since it is soluble in saline.
What is considered a high RNP result?
A titer of ≥ 1:160 was considered positive. Positive RNP ab results (> 1 antibody index (AI)) were characterized as either low (1-3 AI) or high (>3 AI).
What is considered high RNP?
What is the difference between lupus and mixed connective tissue disease?
Mixed Connective Tissue Disease (MCTD) is an autoimmune disorder that shows the features of three different connective tissue disease types: Systemic Lupus Erythematosus (SLE). Systemic Lupus Erythematosus (SLE) is an autoimmune disease that can cause inflammation and tissue damage.
What is considered a high RNP antibody?
For example, according to one laboratory, the following parameters are accepted: A negative antinuclear ribonucleoprotein (anti-RNP) antibody result is defined as less than 20 U based on enzyme-linked immunoassay (ELISA). A borderline result is defined as 20-25 U. A positive result is defined as more than 26 U.
Does RNP fluctuate?
The anti-RNP antibody titers in SLE seemed to correlate with disease activity. Previous reports have stated that anti-RNP antibody titers do not fluctuate easily throughout the disease course. The present report shows that they do fluctuate in patients with SLE.
What does connective tissue disease do to your body?
Connective Tissue Diseases. Your body is held together by tissues that connect all of the structures in your body. When you have a connective tissue disease, these connecting structures are negatively affected. Connective tissue diseases include autoimmune diseases like rheumatoid arthritis, scleroderma and lupus.