What is colloid thyroglobulin?
Thyroglobulin is an essential substrate for organification and is the major protein component of the colloid in the thyroid follicular lumen. It is an iodinated glycoprotein with a molecular weight approximating 650,000 daltons. It consists of two monomeric chains, each with 67 tyrosine residues.
What is iodinated thyroglobulin?
Tg is a large 660-kDa glycosylated protein that acts as a precursor protein for the active iodinated forms of thyroid hormone.
What does colloid do in the thyroid?
part of thyroid gland …with a fluid known as colloid that contains the prohormone thyroglobulin. The follicular cells contain the enzymes needed to synthesize thyroglobulin, as well as the enzymes needed to release thyroid hormone from thyroglobulin.
What is meant by Organification of thyroglobulin?
Organification is a biochemical process that takes place in thyroid gland. It is the incorporation of iodine into thyroglobulin for the production of thyroid hormone, a step done after the oxidation of iodide by the enzyme thyroid peroxidase (TPO).
What if thyroglobulin is low?
If thyroglobulin levels decrease or disappear after treatment, it may mean there are no normal or cancerous thyroid cells left in the body. See if cancer has returned after successful treatment.
What causes colloid cyst thyroid?
Colloid nodular goiters are also known as endemic goiters and are usually caused by inadequate iodine in diet. They tend to occur in certain geographical areas with iodine-depleted soil, usually areas away from the sea coast.
Is colloid goiter cancerous?
Colloid nodules: These are one or more overgrowths of normal thyroid tissue. These growths are benign (not cancer). They may grow large, but they do not spread beyond the thyroid gland.
What does high thyroglobulin mean?
Your thyroglobulin levels are high and/or have increased over time. This may mean thyroid cancer cells are growing, and/or cancer is starting to spread. Little or no thyroglobulin was found. This may mean that your cancer treatment has worked to remove all thyroid cells from your body.
What are thyroglobulin antibodies high?
If you have high levels of antithyroglobulin antibodies in your blood, it may be a sign of serious autoimmune disorder, such as Graves’ disease or Hashimoto thyroiditis. In some cases, you may have antithyroglobulin antibodies in your blood without any specific complications.