What is malondialdehyde used for?

Malondialdehyde (MDA) is the most frequently used biomarker of oxidative stress in many health problems such as cancer, psychiatry, chronic obstructive pulmonary disease, asthma, or cardiovascular diseases.

What is malondialdehyde in the body?

Malondialdehyde (MDA) is one of the final products of polyunsaturated fatty acids peroxidation in the cells. An increase in free radicals causes overproduction of MDA. Malondialdehyde level is commonly known as a marker of oxidative stress and the antioxidant status in cancerous patients.

What is a TBA test?

Sensory Evaluation of Oils/Fats and Oil/Fat–Based Foods The thiobarbituric acid (TBA) test measures malonaldehyde (MDA) produced due to the oxidation of fatty acids with three or more double bonds, and it measures other TBA reactive substances such as 2-alkenals and 2,4-alkadienals.

Is malondialdehyde harmful?

Malondialdehyde (MDA) is the principal and most studied product of polyunsaturated fatty acid peroxidation. This aldehyde is a highly toxic molecule and should be considered as more than just a marker of lipid peroxidation.

What causes malondialdehyde?

Malondialdehyde. MDA is generated by the peroxidation of membrane polyunsaturated fatty acids (Esterbauer et al., 1991). MDA is also produced in the process of prostaglandin synthesis (Marnett, 2002).

How do I lower malondialdehyde?

The combination of aerobic exercise and melatonin reduces the exercise induced-free radicals agents. Melatonin supplementation, especially while it combined with aerobic training, could decrease the lipid peroxidation and malondialdehyde.

How does TBARS assay work?

TBARS assay method It is often considered a good index of the level of oxidative stress in a biological sample. In the assay, thiobarbituric acid reacts with MDA to form a red product which can be detected using a colorimetric (OD = 532 nm) or fluorometric (Ex/Em 532/553 nm) plate reader.