What is the RAD51C gene?
RAD51C (RAD51 Paralog C) is a Protein Coding gene. Diseases associated with RAD51C include Breast-Ovarian Cancer, Familial 3 and Fanconi Anemia, Complementation Group O. Among its related pathways are Homologous DNA Pairing and Strand Exchange and Cell Cycle, Mitotic.
What cancers are caused by BRCA gene?
Women who have a BRCA1 or BRCA2 genetic mutation are at an increased risk of breast, ovarian, and pancreatic cancers. Men who have a BRCA1 or BRCA2 genetic mutation are at an increased risk of prostate, pancreatic, and breast cancers.
What causes HBOC?
Most cases of HBOC syndrome are caused by certain mutations (changes) in the BRCA1 or the BRCA2 gene. People with HBOC syndrome may also have an increased risk of other types of cancer, including pancreatic cancer, prostate cancer, and melanoma. Also called hereditary breast and ovarian cancer syndrome.
Does BRCA cause other cancers?
When a mutation damages either of these genes, the person’s risk of cancer increases. Inheriting damaged copies of the BRCA1 or BRCA2 genes can increase the risk for breast cancer and ovarian cancer in women and the risk for breast and prostate cancer in men, as well as other cancers.
How common is RAD51C mutation?
Germline mutations in RAD51C have been identified in about 1% of hereditary breast and ovarian cancer families. RAD51C mutations are predominantly found in families with a history of ovarian cancer and are rare in families with a history of breast cancer alone. RAD51C is primarily an ovarian cancer susceptibility gene.
How common is RAD51C?
The prevalence of RAD51C mutations was significantly higher in OC patients (0.63%) than in population controls (0.11%), giving a cumulative OR = 5.59 (95%CIs:4.42–7.07; p < 0.0001) and ORadj = 5.04 (95%CIs:3.85–6.59; p < 0.0001).
What happens if you test positive for the BRCA gene?
A positive test result indicates that a person has inherited a known harmful variant in BRCA1 or BRCA2 (these are typically called “pathogenic” or “likely pathogenic” variants on laboratory test reports) and has an increased risk of developing certain cancers.
How common is HBOC syndrome?
In individuals of Ashkenazi Jewish descent, HBOC syndrome affects about 1 in 40 people. Sometimes, this is due to a founder effect.
Does HER2 positive run in families?
HER2-positive breast cancer is not hereditary, but some other types of gene mutations related to breast cancer are inherited. Genetic testing can tell you if you have any of the mutations currently known to increase risk for breast cancer or other cancers.