What does BRG1 stand for?

Brahma-related gene-1 (BRG1), the central catalytic subunit of numerous chromatin-modifying enzymatic complexes, uses the energy derived from ATP-hydrolysis to disrupt the chromatin architecture of target promoters.

What does SMARCA4 stand for?

SMARCA4 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily A, Member 4) is a Protein Coding gene.

How does SWI SNF work?

The SWI/SNF subfamily provides crucial nucleosome rearrangement, which is seen as ejection and/or sliding. The movement of nucleosomes provides easier access to the chromatin, allowing genes to be activated or repressed.

Which of the following is a difference between regulatory proteins with leucine?

Which of the following is a difference between regulatory proteins with leucine zipper and helix-turn-helix DNA binding motifs? Proteins with leucine zippers have two different recognition helices, while proteins with helix-turn-helix motifs are made of two identical units.

What is SMARCA2 gene?

The SMARCA2 gene provides instructions for making one piece (subunit) of a group of similar protein complexes known as SWI/SNF complexes. These complexes regulate gene activity (expression) by a process known as chromatin remodeling. Chromatin is the network of DNA and proteins that packages DNA into chromosomes.

What do miRNAs and siRNAs have in common?

siRNAs and miRNAs share many similarities, both are short duplex RNA molecules that exert gene silencing effects at the post-transcriptional level by targeting messenger RNA (mRNA), yet their mechanisms of action and clinical applications are distinct.

What does leucine do in the leu operon?

This allows RNA polymerase to transcribe the operon. At least 6 amino acid operons are known to be regulated by attenuation….

Leucine operon leader
PDB structures PDBe

What is the role of BRG1 in breast cancer?

In our studies, fast proliferating breast cancer cell lines (MDA-MB-231 and MCF7), BRG1, a component of the SWI/SNF complex, emerges as an activator of functionally-linked genes responsible for activities such as mitotic cell divisions and DNA repair.

What is the BRCA1 gene made of?

The BRCA1 gene contains 22 exons spanning about 110 kb of DNA. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC).

What is the RB1 gene?

RB1 (RB Transcriptional Corepressor 1) is a Protein Coding gene. Diseases associated with RB1 include Retinoblastoma and Small Cell Cancer Of The Lung. Among its related pathways are Gastric cancer and Bladder cancer. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and enzyme binding.

What is the BRCA1-associated genome surveillance complex?

Part of the BRCA1-associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the MRE11-RAD50-NBN protein (MRN) complex (PubMed:10783165). This association could be a dynamic process changing throughout the cell cycle and within subnuclear domains (PubMed:10783165).