What are the long term side effects of capecitabine?

Long-term side effects of Xeloda can include developing certain heart problems or kidney failure. These could last a long time or even be permanent. Xeloda may also cause a long-term loss of fertility. After taking the drug, it may not be possible to become pregnant or make someone pregnant.

What is the test for DPD deficiency?

In the US, DPYD genotyping is the main test used to determine a DPD deficiency, which is defined as the presence of one or more variant DPYD alleles that are known to result in a DPD protein with partial or complete loss of function.

Is capecitabine an immunosuppressant?

Capecitabine Can Induce T Cell Apoptosis: A Potential Immunosuppressive Agent With Anti-Cancer Effect.

Does capecitabine affect eyesight?

Some medications such as capecitabine, cytarabine, doxorubicin, and fluorouracil may contribute to the development of watery eyes.

Can you take vitamins with Xeloda?

Interactions between your drugs No interactions were found between Vitamin D3 and Xeloda. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Does Xeloda cause anemia?

Common side effects of Xeloda include: anemia, diarrhea, hyperbilirubinemia, increased serum alkaline phosphatase, increased serum transaminases, nausea, neutropenia, palmar-plantar erythrodysesthesia, paresthesia, stomatitis, thrombocytopenia, and vomiting. Other side effects include: erythema of skin.

Do you have DPD deficiency?

Kathy is a Fight CRC Research Advocate in the RATS Program. I have stage IV colon cancer and I have a partial DPD deficiency. DPD is short for a very long, hard-to-pronounce enzyme that our bodies make ( dihydropyrimidine dehydrogenase ). Complete deficiency is rare, and only 3-6% of the population has partial DPD deficiency.

What are the effects of DPD deficiency on chemotherapy?

With deficient enzyme function, patients can experience severe toxicities with standard doses of fluoropyrimidine chemotherapy. 1 While the incidence of DPD deficiency is relatively low, ranging from 1 to 7 percent of the population depending on ancestry, 2 the consequences are potentially fatal.

Should screening for DPD deficiency be performed in fluorouracil patients?

Screening for Dihydropyrimidine Dehydrogenase (DPD) Deficiency in Fluorouracil Patients: Why Not? ISMP is aware of several reports of patients who suffered severe toxicities or even death from the fluoropyrimidine chemotherapy drugs, fluorouracil and capecitabine ( XELODA ), an oral prodrug that is metabolized to fluorouracil after ingestion.

What is a DPD deficiency in colorectal cancer?

DPD is short for a very long, hard-to-pronounce enzyme that our bodies make (dihydropyrimidine dehydrogenase). Complete deficiency is rare, and only 3-6% of the population has partial DPD deficiency. In talking about DPD strictly in the context of colorectal cancer, this enzyme helps our bodies break down 5FU and capecitabine (xeloda®).