What can cause diffuse alveolar damage?

Diffuse alveolar damage (DAD) is a relatively common histopathologic pattern seen on surgical lung biopsies and can be caused by infections, drugs, inhalational injuries, connective tissue diseases, and other forms of insult.

Which drug causes lung damage?

Cytotoxic Drugs Any chemotherapeutic drug can adversely affect the lung, but the drugs most commonly implicated in lung toxicity are bleomycin, carmustine, busulfan, and cyclophosphamide [43-46]. Approximately 1-10% of patients taking one of these drugs are affected.

What drugs cause breathing problems?

List of Drugs that may cause Difficulty In Breathing (Dyspnea)

  • Agalsidase.
  • Alglucosidase.
  • Anagrelide.
  • Anidulafungin.
  • Cilostazol.
  • Crizotinib.
  • Denileukin Diftitox.
  • Epoprostenol.

What is diffuse alveolar damage in the lungs?

Diffuse alveolar damage (DAD) is a histologic term used to describe specific changes that occur to the structure of the lungs during injury or disease. Most often DAD is described in association with the early stages of acute respiratory distress syndrome (ARDS).

Is diffuse alveolar damage fatal?

Diffuse alveolar damage (DAD) is the morphological prototype of acute interstitial pneumonia and is characterised by a rapid and fatal clinical course.

What medications can cause lung scarring?

Some of the commoner medication types that are known to carry the risk of pulmonary fibrosis include certain:

  • antibiotics, particularly nitrofurantoin.
  • immunosuppressant drugs, such as methotrexate.
  • drugs for heart conditions, particularly amiodarone.
  • cancer chemotherapy drugs.

Which drugs cause pulmonary edema?

Many drugs — ranging from aspirin to illegal drugs such as heroin and cocaine — are known to cause pulmonary edema. Blood clot in the lungs (pulmonary embolism). If a blood clot travels from the blood vessels in your legs to your lungs, you can develop pulmonary edema.

How is drug-induced pulmonary toxicity treated?

The treatment of drug-induced lung disease consists of immediately discontinuing the offending drug and appropriately managing the pulmonary symptoms. Acute episodes of drug-induced pulmonary disease usually disappear 24-48 hours after the drug has been discontinued, but chronic syndromes may take longer to resolve.

What drugs cause pulmonary edema?

What drugs cause fluid in the lungs?

Additional drugs that can cause noncardiogenic pulmonary edema include carbamazepine, cytarabine, erythromycin, hydrochlorothiazide, IV radiographic contrast agents, methotrexate, protamine, tamoxifen, and tumor necrosis factor.

What are diffuse alveolar infiltrates?

Diffuse alveolar hemorrhage is persistent or recurrent pulmonary hemorrhage. There are numerous causes, but autoimmune disorders are most common. Most patients present with dyspnea, cough, hemoptysis, and new alveolar infiltrates on chest imaging. Diagnostic tests are directed at the suspected cause.