What is vecuronium bromide used for?
Vecuronium bromide is an FDA-approved peripherally acting, monoquarternary, steroidal, non-depolarizing neuromuscular blocker with an intermediate duration of action used during general anesthesia to facilitate endotracheal intubation, to aid in surgical relaxation, and, less commonly, in the intensive care setting to …
How is vecuronium bromide administered?
The recommended initial dose of vecuronium bromide is 0.08 to 0.1 mg/kg (1.4 to 1.75 times the ED90) given as an intravenous bolus injection. This dose can be expected to produce good or excellent non-emergency intubation conditions in 2.5 to 3 minutes after injection.
How do you store vecuronium?
20 mg vecuronium bromide, NDC 0069-0108-05 Box of 10. Store dry powder at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature]. Protect from light. Retain in carton until time of use.
How do you mix vecuronium drip?
Infusion solutions of vecuronium can be prepared by mixing vecuronium with an appropriate infusion solution such as Dextrose Injection 5%, Sodium Chloride Injection 0.9%, Dextrose (5%) and Sodium Chloride Injection, or Lactated Ringer’s Injection. Unused portions of infusion solutions should be discarded.
What type of drug is vecuronium?
Vecuronium is a nondepolarizing neuromuscular blocking agent used to relax muscles or as an adjunct in general anesthesia during surgical procedures. Monoquaternary homolog of pancuronium. A non-depolarizing neuromuscular blocking agent with shorter duration of action than pancuronium.
Can vecuronium cause death?
Risk of Death due to Medication Errors Administration of vecuronium bromide results in paralysis, which may lead to respiratory arrest and death; this progression may be more likely to occur in a patient for whom it is not intended.
How do you administer a vecuronium injection?
How do you use a vecuronium?
Vecuronium is injected into a muscle, or into a vein through an IV. A healthcare provider will give you this injection. Your breathing, blood pressure, oxygen levels, heart function, and other vital signs will be watched closely while you are receiving vecuronium.
How long will vecuronium last?
With succinylcholine as the intubating agent, initial doses of 0.04 to 0.06 mg/kg of vecuronium will produce complete neuromuscular block with clinical duration of action of 25-30 minutes.
Is vecuronium a powder?
NDC 67457-438-10 – Rx only – Vecuronium Bromide for Injection – 10 mg* WARNING: Paralyzing Agent – Lyophilized Powder – For IV Single Dose Only – *1 mg/mL when reconstituted to 10 mL – Mylan – 10 x 10 mg …
How do you give a vecuronium infusion?
CONTINUOUS INFUSION: Initiate with an intubating dose of 80 to 100 mcg/kg followed 20 to 40 minutes later with 1 mcg/kg/minute. -Infuse this drug only after early evidence of spontaneous recovery from the bolus dose.
What is another name for vecuronium?
Vecuronium bromide, sold under the brand name Norcuron among others, is a medication used as part of general anesthesia to provide skeletal muscle relaxation during surgery or mechanical ventilation.
What is vecuronium bromide for injection?
Vecuronium Bromide for Injection is a nondepolarizing neuromuscular blocking agent of intermediate duration, chemically designated as 1-(3α,17β-Dihydroxy-2β-piperidino-5α-androstan-16β,5α-yl)-1-methylpiperidinium bromide, diacetate. Vecuronium Bromide USP is a white or creamy white crystalline powder.
What are the contraindications for vecuronium bromide?
Vecuronium bromide is contraindicated in patients known to have a hypersensitivity to it. Anaphylaxis: Severe anaphylactic reactions to neuromuscular blocking agents, including Vecuronium bromide, have been reported. These reactions have in some cases been life-threatening and fatal.
Can you mix reconstituted vecuronium bromide with thiopental?
Reconstituted vecuronium bromide, which has an acid pH, should not be mixed with alkaline solutions (e.g., barbiturate solutions such as thiopental) in the same syringe or administered simultaneously during intravenous infusion through the same needle or through the same intravenous line.
When should a continuous infusion of vecuronium be initiated?
After an intubating dose of 80 to 100 mcg/kg, a continuous infusion of 1 mcg/kg/min can be initiated approximately 20-40 min later. Infusion of Vecuronium should be initiated only after early evidence of spontaneous recovery from the bolus dose.