Which is an example of antisense technology?

For example, an antisense oligonucleotide inhibitor of an apo-B protein is used to treat Familial Homozygous Hypercholesterolaemia. Apo-B is an essential structural component of lipoproteins. By halting the translation of apo-B, their plasma concentrations decrease, leading to a reduced risk of coronary heart disease.

Who discovered antisense technology?

Introduction. The potential of oligodeoxynucleotides to act as antisense agents that inhibit viral replication in cell culture was discovered by Zamecnik and Stephenson in 1978 [[1]]. Since then antisense technology has been developed as a powerful tool for target validation and therapeutic purposes.

What is the meaning of antisense technology?

Antisense DNA technology is a method to inhibit or downregulate the production of a target protein by using antisense DNA or RNA molecules. An antisense sequence is a DNA or RNA that is perfectly complementary to the target nucleotide sequence present in the cell.

What is a difference between the sense and antisense strands of DNA?

The main difference between sense and antisense strand is that sense strand is incapable of being transcribed into mRNA whereas antisense strand serves as the template for the transcription.

Why is the antisense strand important?

‚ÄčAntisense Antisense is the non-coding DNA strand of a gene. In a cell, antisense DNA serves as the template for producing messenger RNA (mRNA), which directs the synthesis of a protein.

What is ribozyme technology?

Ribozyme Technology means all inventions, improvements or other developments relating to Ribozymes, including the identification, manufacture, synthesis, delivery, use, enhancement and control of Ribozymes conceived or reduced to practice by Thomas Cech, Ph.

What is the difference between the sense and antisense strand?

Is antisense therapeutics a real company?

Antisense Therapeutics is an Australian publicly-listed biotechnology company, developing and commercializing antisense pharmaceuticals for large unmet markets in rare diseases. The products are in-licensed from Ionis Pharmaceuticals Inc. (NASDAQ: IONS), an established leader in antisense drug development.

Is sense or antisense coding?

The sense strand has the information that would be readable on the RNA, and that’s called the coding side. The antisense is the non-coding strand, but ironically, when you’re making RNA, the proteins that are involved in making RNA read the antisense strand in order to create a sense strand for the mRNA.

What is antisense technology and its application?

ANTISENSE TECHNOLOGY AND ITS APPLICATION INTRODUCTION: The tool that is used for the inhibition of gene expression is called Antisense technology. The antisense nucleic acid sequence base pairs with its complementary sense RNA strands and thus prevents it from being translated into a protein.

Is antisense technology the future of cancer chemotherapy?

Antisense technology may play a major role in cancer chemotherapy. It is clearly a tool of therapy. Additionally, there is now substantial voidance that antisense drugs are safe, and a growing efficacy in patients with cancer.

What are the differences between the different antisense strategies?

Comparison of different antisense strategies. While most of the conventional drugs bind to proteins, antisense molecules pair with their complementary target RNA. Antisense-oligonucleotides block translation of the mRNA or induce its degradation by RNase H, while ribozymes and DNA enzymes possess catalytic activity and cleave their target RNA.

What are some of the best books on antisense technology?

Richard R. (2000) The application of antisense technology to medicine. The Ochsner Journal. (2): 233- 236. 44. Scherer L.J. and Rossi J.J. (2003) Approaches for the sequence specific knockdown of mRNA. Nat. Biotech. (21): 1457-1463.